Brock Purdy may return for the 49ers' home game against Arizona, with a turf-toe recovery that could allow limited practice this week. If he suits up, SF’s fantasy upside remains bright with Kittle and Jennings as primary targets and Tonges lurking as a Week 1 hero. In Week 2, Mac Jones orchestrated a surprising SF debut with 279 yards and 3 TDs, a sign the backup QB path can still produce fantasy dividends. Arizona starts 2-0 but hasn’t topped 300 yards in a game, hinting at potential regression as SF’s defense clamps down.

Week 1 saw Purdy deliver a late TD pass to Tonges, while Seattle loomed as the opener. The Cards’ offense, led by Kyler Murray, has been productive enough to win without explosive totals. The Week 3 clash will test Purdy’s health and the 49ers’ depth, with implications for Kittle, Jennings, Tonges and the backfield in fantasy lineups.

Panthers host Atlanta as Bryce Young faces a 0-2 start, but Canales remains confident in the rookie’s trajectory. Young has completed 58.9% with 3 interceptions and 3 TDs through two games, while chemistry grows with Tremayne, Renfrow and McMillan. A home opener against a Falcons defense that just wrecked Minnesota is Carolina’s latest test of Young’s progression.

Brock Purdy’s Week 3 availability is the central question for the 49ers as toe and shoulder issues collide with a home matchup against Arizona. A limited practice window keeps Purdy in play, but San Francisco has Mac Jones ready if Purdy can’t go. The team also navigates McCaffrey’s calf/rest schedule, Bosa and Williams’ vet days, and Jennings/Juszczyk injuries, while Ben Bartch lands on IR and rookie Connor Colby steps in at left guard.

Fantasy managers should monitor Purdy’s status; if he starts, the offense maintains a reasonable floor with potential upside in a plus matchup. If Jones starts, San Francisco shifts to a more conservative plan with McCaffrey as the centerpiece and Colby stabilizing the line for a run-focused attack against Arizona.

Brock Purdy could return to practice in a limited capacity ahead of Week 3 after a toe injury, raising optimism for a possible Week 3 return or emergency third QB setup vs Arizona. Eight 49ers missed practice, including Kyle Juszczyk and Siran Neal with concussions and key vets like Trent Williams, Nick Bosa, and Christian McCaffrey on rest days or limited designations. The latest timeline hints Purdy could be back sooner than feared, with a two-week recovery being plausible.

Fantasy angle: Purdy’s return would reshape San Francisco’s aerial ceiling, while McCaffrey’s workload is a key watch given the injury designations. Jennings and Williams are trending to play, but neck-and-neck with health; Juszczyk/Neal concussion protocols add depth risk. Week 3 game plan against Arizona looms large for SF’s offense and fantasy upside.